Most drain advice online falls into two categories. Things that do nothing, and things that damage your pipes while doing nothing. Here is what is actually worth your time.
Start with hot water and enzymes, not chemicals
For a drain that is slow rather than stopped, the routine that works is unglamorous. Run the hottest tap water you have for a couple of minutes to soften grease and soap film. Then use an enzyme-based drain treatment overnight, when nobody will run water through it.
Enzyme products work by digesting organic buildup. They are slow, which is why people skip them, and they are the safest thing you can put in an older pipe. Used monthly, they prevent more clogs than any single-use fix ever clears.
Stop using caustic drain cleaners
The bottles sold at every hardware store work by generating heat and dissolving the blockage chemically. Three problems with that in Mesa homes.
They damage older pipe. Plenty of Mesa houses still have galvanized steel or older PVC, and repeated chemical exposure degrades both.
They frequently do not clear the clog, they just soften a channel through it. The blockage comes back, and now there is caustic liquid sitting in your trap.
They make the eventual professional visit more dangerous. When a plumber opens a line full of drain cleaner, that liquid goes somewhere. Tell us if you have used it. We would rather know.
The mechanical fixes worth learning

A cup plunger for sinks, a flange plunger for toilets. They are different tools and most homes only own the wrong one. Fill the basin with enough water to cover the plunger cup, block the overflow opening with a wet rag so you are not just moving air, and use steady pushes rather than violent ones.
A drain snake for hair clogs. A cheap plastic hair-catching strip clears most bathroom sink and shower clogs in about a minute. Hair and soap scum bind together tightly in hard water, and this is the single most common residential clog in Mesa.
Drain covers. Boring, cheap, and they prevent the majority of the clogs above from ever forming.
The Mesa-specific part
Hard water makes drain problems worse in a way that is easy to miss. Soap scum is the chemical result of soap reacting with the calcium and magnesium in your water, and Mesa runs 12 to 16 grains per gallon. That means more scum, formed faster, binding hair into a firmer mass.
Scale also builds on the interior of drain lines the same way it builds inside supply pipes, narrowing them over years. A drain that has been “a bit slow” for a decade in a Mesa house may not have a clog at all. It may have a smaller pipe than it started with, and no amount of plunging fixes that.